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As a result, these in vitro culture approaches that predominantly exhibit the activated (aVIC) phenotype may not reliably represent the process of VIC activation or the characteristics of a healthy valve

10.1016/j.lfs.2021.120087 159 PavithraK.Sathibabu UddandraoV

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423,427 An inspiring result has shown that a drug cocktail restores cognitive impairment, neuroinflammation, and A aggregation while enhancing autophagy and synaptic integrity in AD mice, especially in females

199 In bladder cancer, METTL3 is significantly overexpressed in patient-derived samples and facilitates the advancement of bladder cancer through the AFF4/NF-B/MYC signaling cascade

Postmortem studies of PD brains have demonstrated microglial activation in the substantia nigra pars compacta (SNpc), characterized by increased expression of markers such as HLA-DR, CD68, and Iba-1, along with elevated production of pro-inflammatory mediators including IL-1, TNF-, IL-6, and reactive oxygen species (ROS) [73]